Fusion proteins comprising an angiostatin moiety and their use in anti-tumour treatment
The present invention relates to the development of novel multi-functional proteins (MFPs) of the formula: R 1 -L 1 -R 2 , R 2 -L 1 -R 1 , R 1 -L 1 -R 1 , R 1 -R 2 , R 2 -R 1 , or R 1 -R 1 where R 1 is angiostatin, R 2 is selected from endostatin, human type I interferon, thrombospondin, interferon-...
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Main Authors | , , , , , |
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Format | Patent |
Language | English French German |
Published |
27.09.2006
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Abstract | The present invention relates to the development of novel multi-functional proteins (MFPs) of the formula: R 1 -L 1 -R 2 , R 2 -L 1 -R 1 , R 1 -L 1 -R 1 , R 1 -R 2 , R 2 -R 1 , or R 1 -R 1 where R 1 is angiostatin, R 2 is selected from endostatin, human type I interferon, thrombospondin, interferon-inducible protein 10, platelet factor 4, and L 1 is a linker capable of linking R 1 to R 2 . The invention is also drawn to nucleic acids that encode MFPs, procedures for manufacturing MFPs, methods of using MFPs, methods of treating angiogenic-mediated disease with MFPs including methods of treating tumors with MFPs, and treating tumors by gene therapy using vectors that encode MFPs. |
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AbstractList | The present invention relates to the development of novel multi-functional proteins (MFPs) of the formula: R 1 -L 1 -R 2 , R 2 -L 1 -R 1 , R 1 -L 1 -R 1 , R 1 -R 2 , R 2 -R 1 , or R 1 -R 1 where R 1 is angiostatin, R 2 is selected from endostatin, human type I interferon, thrombospondin, interferon-inducible protein 10, platelet factor 4, and L 1 is a linker capable of linking R 1 to R 2 . The invention is also drawn to nucleic acids that encode MFPs, procedures for manufacturing MFPs, methods of using MFPs, methods of treating angiogenic-mediated disease with MFPs including methods of treating tumors with MFPs, and treating tumors by gene therapy using vectors that encode MFPs. |
Author | MCKEARN, JOHN P GREGORY, SUSAN A KLEIN, BARBARA K CAPARON, MAIRE H BOLANOWSKI, MARK A CASPERSON, GERALD F |
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DocumentTitleAlternate | Protéines de fusion comprenant une fraction d'angiostatine et leur utilisation dans un traitement ant-tumeur Fusionsproteine mit einem angiostatin-Anteil und deren Anwendung in Antitumortherapie |
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Snippet | The present invention relates to the development of novel multi-functional proteins (MFPs) of the formula: R 1 -L 1 -R 2 , R 2 -L 1 -R 1 , R 1 -L 1 -R 1 , R 1... |
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Title | Fusion proteins comprising an angiostatin moiety and their use in anti-tumour treatment |
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