Fusion proteins comprising an angiostatin moiety and their use in anti-tumour treatment

• Main Authors: GREGORY, SUSAN A, KLEIN, BARBARA K, CAPARON, MAIRE H, CASPERSON, GERALD F, BOLANOWSKI, MARK A, MCKEARN, JOHN P
• Format: Patent
• Language: English; French; German
• Published: 27.09.2006
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to the development of novel multi-functional proteins (MFPs) of the formula: R 1 -L 1 -R 2 , R 2 -L 1 -R 1 , R 1 -L 1 -R 1 , R 1 -R 2 , R 2 -R 1 , or R 1 -R 1 where R 1 is angiostatin, R 2 is selected from endostatin, human type I interferon, thrombospondin, interferon-inducible protein 10, platelet factor 4, and L 1 is a linker capable of linking R 1 to R 2 . The invention is also drawn to nucleic acids that encode MFPs, procedures for manufacturing MFPs, methods of using MFPs, methods of treating angiogenic-mediated disease with MFPs including methods of treating tumors with MFPs, and treating tumors by gene therapy using vectors that encode MFPs.