REGULATION OF MATRIX METALLOPROTEINASES BY PSP94 FAMILY MEMBERS
Matrix metalloproteinases (MMPs) play an important role in morphogenesis, angiogenesis, wound healing, and in certain disorders such as rheumatoid arthritis, tumor invasion and metastasis. MMPs are thought to be regulated by a variety of cytokines, growth factors, hormones and phorbol esters. This r...
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Main Authors | , , , , |
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Format | Patent |
Language | English French German |
Published |
28.02.2007
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Subjects | |
Online Access | Get full text |
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Summary: | Matrix metalloproteinases (MMPs) play an important role in morphogenesis, angiogenesis, wound healing, and in certain disorders such as rheumatoid arthritis, tumor invasion and metastasis. MMPs are thought to be regulated by a variety of cytokines, growth factors, hormones and phorbol esters. This regulation occurs on three levels; alteration of gene expression, activation of the latent zymogen and inhibition by the tissue inhibitors of metalloproteinases (TIMP). We report here a new agent that regulates the level of MMPs. |
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Bibliography: | Application Number: EP20040786679 |