NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS

• Main Authors: CORRETTE, CHRISTOPHER, PETER, KORI, M, GYOTEN, M, CHO, SUK, YOUNG, TURNER, TIMOTHY, MARK, PRATT, SCOTT, ALAN, GYORKOS, ALBERT, CHARLES, ASO, K
• Format: Patent
• Language: English; French; German
• Published: 12.07.2006
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

There is provided a CRF receptor antagonist comprising a compound of the formula (I): wherein, ring A is a 5-membered ring represented by the formula (A′): wherein X is a carbon and X1 is an oxygen, a sulfur or -NR5-, or formula (A″): wherein X is a nitrogen and R6 is an optionally substituted hydrocarbyl, R1 is an amino substituted by two optionally substituted hydrocarbyl groups, R2 is an phenyl, Y1 is CR3a or a nitrogen, Y2 is CR3b or a nitrogen and Y3 is CR3c or a nitrogen, provided that one or less of Y1, Y2, and Y3 is nitrogen, W is a bond, -(CH2)n-, and Z is a bond, -NR4-, etc.; or a salt thereof or a prodrug thereof.