INDUCTION OF ANTIVIRAL NEUTRALIZING ANTIBODIES IN HUMANS AND ANIMALS

The invention relates to immunogenic constructs that in principle comprise two different domains of the transmembrane envelope protein of enveloped viruses including retroviruses including HIV, a pharmaceutical agent for inducing humoral neutralizing immune responses to viral infections and to a kit...

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Bibliographic Details
Main Authors FIEBIG, UWE, KURTH, REINHARDT, DENNER, JOACHIM, SCHMOLKE, MIRCO, KARLAS, ALEXANDER
Format Patent
LanguageEnglish
French
German
Published 31.05.2006
Edition7
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to immunogenic constructs that in principle comprise two different domains of the transmembrane envelope protein of enveloped viruses including retroviruses including HIV, a pharmaceutical agent for inducing humoral neutralizing immune responses to viral infections and to a kit for the detection of antibodies and viral antigens. The invention also relates to a method for inducing an antibody response and to a method for the passive immunization of an organism using neutralizing antibodies that were obtained using the above-mentioned immunogenic constructs. Finally, the invention relates to a bioassay for detecting viral infection and for detecting the production of neutralizing antibodies.
Bibliography:Application Number: EP20040786181