PHTHALAZINONE DERIVATIVES

Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NR or CRR; if X NR then n is 1 or 2 and if X = CRR then n is 1; R is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl,...

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Main Authors ASHWORTH, ALAN, JACKSON, STEPHEN PHILIP, COCKCROFT, XIAO-LING FAN, MENEAR, KEITH ALLAN, LOH, VINCENT, JUNIOR, M, MARTIN, NIALL MORRISON B, SMITH, GRAEME CAMERON M, MATTHEWS, IAN TIMOTHY WILLIAMS, KERRIGAN, FRANK
Format Patent
LanguageEnglish
French
German
Published 15.03.2006
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NR or CRR; if X NR then n is 1 or 2 and if X = CRR then n is 1; R is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; R is selected from H, hydroxy, amino; or R and R may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; R and R are both hydrogen, or when X is CR R, R, R, R and R, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R is selected from H and halo.
Bibliography:Application Number: EP20040720068