CHROMENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS

• Main Authors: ASTON, KARL, W, YU, YI, HAMPER, BRUCE, C, KOSZYK, FRANCIS, WANG, LIJUAN, JANE, LIMBURG, DAVID, HALLINAN, E., ANN, SPRINGER, JOHN, R, TSYMBALOV, SOFYA, BROWN, DAVID, L, KIEFER, JAMES, R, CARTER, JEFFREY, S, HUFF, RENEE, M, XING, LI, FLETCHER, THERESA, R, LIAO, SUBO, DEPROW, ANGELA, M, KRAMER, STEVEN, W
• Format: Patent
• Language: English; French; German
• Published: 08.03.2006
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula 1 Wherein Z, X, R1, R2, R3, and R4 are as described in the specification.