TETRAZOLE AND OXADIAZOLONE SUBSTITUTED beta-AMINO ACID DERIVATIVES

This invention relates to novel tetrazole and oxadiazalone beta-amino acids derivatives of the formula wherein G is wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disor...

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Main Authors SCHWARZ, JACOB BRADLEY, HUDACK, RAYMOND ANDREW JR, THORPE, ANDREW JOHN, BARTA, NANCY SUE, ZHU, ZHIJIAN, LIN, KRISTIN KNAPP, COLBRY, NORMAN LLOYD, WUSTROW, DAVID JUERGEN
Format Patent
LanguageEnglish
French
German
Published 14.12.2005
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:This invention relates to novel tetrazole and oxadiazalone beta-amino acids derivatives of the formula wherein G is wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl beta-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (alpha2delta ligands). Such compounds have affinity for the alpha2delta subunit of a calcium channel.
Bibliography:Application Number: EP20040713604