Combination of alkane diol and hydroxy acid for the treatment of acne

New cosmetic and/or dermatological preparations (A) contain an active agent combination or one or more alpha - and/or beta -hydroxyacids (I) and one or more alkane-1,2-diols (II), optionally together with other active agents, auxiliaries and additives. ACTIVITY : Dermatological; Antiseborrheic; Anti...

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Main Authors TRAUPE, BERND, FAENGER, SABINE, FILBRY, ALEXANDER, BUERGER, ANETTE, JUNG, SUSANNE
Format Patent
LanguageEnglish
French
German
Published 09.11.2011
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS
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Summary:New cosmetic and/or dermatological preparations (A) contain an active agent combination or one or more alpha - and/or beta -hydroxyacids (I) and one or more alkane-1,2-diols (II), optionally together with other active agents, auxiliaries and additives. ACTIVITY : Dermatological; Antiseborrheic; Antibacterial. In suspension tests for action against Propionibacterium acnesat pH 4.5, a combination of 1% lactic acid (Ia) and 0.2% decane-1,2-diol (IIa) reduced the bacterial count (CFU per ml) from ca. 2 x 10 5>to ca. 2 x 10 2>(compared with ca. 10 4>for 1% (Ia) alone and 10 5>for 0.2% (IIa) alone) in 15 minutes. MECHANISM OF ACTION : None given in the source material.
Bibliography:Application Number: EP20040021126