A process for the formation of disulfide bonds in cyclic peptides

A non-oxidative process is described for the formation of an intramolecular disulfide bond in precursors of the peptide or peptidomimetic type; said process comprises the preparation of a linear intermediate containing an -SH group in the S-sulfonate form and a second -SH group which is obtainable i...

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Bibliographic Details
Main Authors CAPPELLETTI, SILVANA, PINORI, MASSIMO, STARACE, OLIVIA, ANNONI, PAOLA
Format Patent
LanguageEnglish
French
German
Published 13.06.2007
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:A non-oxidative process is described for the formation of an intramolecular disulfide bond in precursors of the peptide or peptidomimetic type; said process comprises the preparation of a linear intermediate containing an -SH group in the S-sulfonate form and a second -SH group which is obtainable in the free form by means of acid treatment.
Bibliography:Application Number: EP20050103219