A PROCESS FOR PREPARING DULOXETINE AND INTERMEDIATES FOR USE THEREIN
A process for making (+)duloxetine or an acid addition salt thereof, comprising reacting intermediate compounds of formulae (I) and (II) so as to yield a compound of formula (III), or an acid addition salt thereof in the presence of a base and a phase transfer catalyst, where one of X and Y is hydro...
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Main Authors | , |
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Format | Patent |
Language | English French German |
Published |
31.01.2007
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Subjects | |
Online Access | Get full text |
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Summary: | A process for making (+)duloxetine or an acid addition salt thereof, comprising reacting intermediate compounds of formulae (I) and (II) so as to yield a compound of formula (III), or an acid addition salt thereof in the presence of a base and a phase transfer catalyst, where one of X and Y is hydroxy and the other is a leaving group, and subjecting a compound of formula (III), or an acid addition salt thereof, to further process steps so as to yield (+) duloxetine, or an acid addition salt thereof, substantially free of (-)duloxetine. |
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Bibliography: | Application Number: EP20030767973 |