HUMANIZED ANTIBODY (H14.18) OF THE MOUSE 14.18 ANTIBODY BINDING TO GD2 AND ITS FUSION WITH IL-2
The invention provides a family of antibodies that specifically bind the human cell surface glycosphingolipid GD2. The antibodies comprise modified variable regions, more specially, modified framework regions, which reduce their immunogenicity when administered to a human. The antibodies may be coup...
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Main Authors | , |
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Format | Patent |
Language | English French German |
Published |
23.06.2010
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Subjects | |
Online Access | Get full text |
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Summary: | The invention provides a family of antibodies that specifically bind the human cell surface glycosphingolipid GD2. The antibodies comprise modified variable regions, more specially, modified framework regions, which reduce their immunogenicity when administered to a human. The antibodies may be coupled to a therapeutic agent and used in the treatment of cancer. |
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Bibliography: | Application Number: EP20030795898 |