RECEPTOR-TYPE KINASE MODULATORS AND METHODS OF USE

The present invention provides a process for preparing compounds for modulating receptor kinase activity, particularly ephrin and EGFR. Diseases mediated by receptor kinase activity include, but are not limited to, diseases characterized in part by abnormal levels of cell proliferation (i.e. tumor g...

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Main Authors ANAND, NEEL, KUMAR, KIM, ANGIE, I, PETO, CSABA, J, BUSSENIUS, JOERG, BLAZEY, CHARLES, M, TSANG, TSZE, H, KENNEDY, ABIGAIL, R, RICE, KENNETH, D, COSTANZO, SIMONA
Format Patent
LanguageEnglish
French
German
Published 11.10.2006
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a process for preparing compounds for modulating receptor kinase activity, particularly ephrin and EGFR. Diseases mediated by receptor kinase activity include, but are not limited to, diseases characterized in part by abnormal levels of cell proliferation (i.e. tumor growth), programmed cell death (apoptosis), cell migration and invasion and angiogenesis associated with tumor growth. Compounds provided by the process of the invention include "spectrum selective" kinase modulators, compounds that inhibit, regulate and/or modulate signal transduction across subfamilies of receptor-type tyrosine kinases, including ephrin and EGFR.
Bibliography:Application Number: EP20030764599