BIOMOLECULE OPEN CHANNEL SOLID PHASE EXTRACTION SYSTEMS AND METHODS

An open capillary channel device for open tubular solid phase extraction of molecules capable of providing a tube enrichment factor of at least 1. The device comprises a channel having one end connected to a pump for pumping liquid and gas, and the other end can be connected to an interface for a pr...

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Bibliographic Details
Main Authors GJERDE, DOUGLAS, T, HANNA, CHRISTOPHER, P
Format Patent
LanguageEnglish
French
German
Published 30.03.2005
Edition7
Subjects
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PHYSICS
SEPARATION
TESTING
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:An open capillary channel device for open tubular solid phase extraction of molecules capable of providing a tube enrichment factor of at least 1. The device comprises a channel having one end connected to a pump for pumping liquid and gas, and the other end can be connected to an interface for a protein chip sample applicator or a mass spectrometer, the inner surface of the channel being an extraction surface. The extraction surface can be bonded to an affinity binding agent. The affinity agent can be a chelated metal, a protein, a sugar or nucleic acid with a binding affinity for a selected analyte. The method using this device comprises binding sample molecules from a sample solution to the affinity extraction surface of the capillary channel; and desorbing a substantial portion of the sample molecules from the extraction surface with a desorbent liquid, with an extraction factor greater than 1.
Bibliography:Application Number: EP20030728775