PROCESS FOR THE SYNTHESIS OF PEPTIDE AMIDES BY SIDE-CHAIN ATTACHMENT TO A SOLID PHASE

A process is provided for the solid-phase synthesis of a peptide amide which comprises attaching an α-nitrogen protected Cα-carboxamide amino acid to a solid support by its side chain, removing the α-nitrogen protecting group, assembling a peptide chain on said α-nitrogen and then cleaving the assem...

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Main Authors ATHERTON, ERIC, WELLINGS, DONALD, ALFRED, SIMPKIN, DEAN, STEVEN, ANTHONY, EVANS, DAVID, JOHN
Format Patent
LanguageEnglish
French
German
Published 09.02.2005
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Abstract A process is provided for the solid-phase synthesis of a peptide amide which comprises attaching an α-nitrogen protected Cα-carboxamide amino acid to a solid support by its side chain, removing the α-nitrogen protecting group, assembling a peptide chain on said α-nitrogen and then cleaving the assembled peptide amide from the solid support. Novel amino acid analogues, peptide amides and solid-phase supports are also provided.
AbstractList A process is provided for the solid-phase synthesis of a peptide amide which comprises attaching an α-nitrogen protected Cα-carboxamide amino acid to a solid support by its side chain, removing the α-nitrogen protecting group, assembling a peptide chain on said α-nitrogen and then cleaving the assembled peptide amide from the solid support. Novel amino acid analogues, peptide amides and solid-phase supports are also provided.
Author ATHERTON, ERIC
WELLINGS, DONALD, ALFRED
SIMPKIN, DEAN, STEVEN, ANTHONY
EVANS, DAVID, JOHN
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DocumentTitleAlternate VERFAHREN ZUR HERSTELLUNG VON PEPTIDAMIDEN DURCH SEITENKETTENANKNÜPFUNG AN EINER FESTPHASE
PROCEDE DE SYNTHESE D'AMIDES DE PEPTIDES PAR FIXATION DES CHAINES LATERALES SUR UNE PHASE SOLIDE
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Snippet A process is provided for the solid-phase synthesis of a peptide amide which comprises attaching an α-nitrogen protected Cα-carboxamide amino acid to a solid...
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SubjectTerms ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Title PROCESS FOR THE SYNTHESIS OF PEPTIDE AMIDES BY SIDE-CHAIN ATTACHMENT TO A SOLID PHASE
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