PROCESS FOR THE SYNTHESIS OF PEPTIDE AMIDES BY SIDE-CHAIN ATTACHMENT TO A SOLID PHASE

A process is provided for the solid-phase synthesis of a peptide amide which comprises attaching an α-nitrogen protected Cα-carboxamide amino acid to a solid support by its side chain, removing the α-nitrogen protecting group, assembling a peptide chain on said α-nitrogen and then cleaving the assem...

Full description

Saved in:
Bibliographic Details
Main Authors ATHERTON, ERIC, WELLINGS, DONALD, ALFRED, SIMPKIN, DEAN, STEVEN, ANTHONY, EVANS, DAVID, JOHN
Format Patent
LanguageEnglish
French
German
Published 09.02.2005
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Online AccessGet full text

Cover

More Information
Summary:A process is provided for the solid-phase synthesis of a peptide amide which comprises attaching an α-nitrogen protected Cα-carboxamide amino acid to a solid support by its side chain, removing the α-nitrogen protecting group, assembling a peptide chain on said α-nitrogen and then cleaving the assembled peptide amide from the solid support. Novel amino acid analogues, peptide amides and solid-phase supports are also provided.
Bibliography:Application Number: EP20030725369