A PROCESS FOR THE PREPARATION OF TABLETS FROM PHARMACEUTICALLY ACTIVE SUBSTANCES HAVING UNFAVOURABLE TABLETTING PROPERTIES WITH A GRANULATING LIQUID COMPRISING MICROCRYSTALLINE CELLULOSE

The invention refers to a process for the preparation of tablets that can be well compressed and have good mechanical strength from pharmaceutically active ingredient(s) having unfavourable tabletting properties. In the process of the invention a granulating liquid is used which is a suspension of 5...

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Bibliographic Details
Main Authors JAMBOR, ISTVANNE, FEKETE, PAL, SZLAVYNE SZELL, ZSUZSA, GORA, LASZLONE, KIRALYNE IGNACZ, MARIA, PALFI, ZOLTANNE
Format Patent
LanguageEnglish
French
German
Published 14.06.2006
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention refers to a process for the preparation of tablets that can be well compressed and have good mechanical strength from pharmaceutically active ingredient(s) having unfavourable tabletting properties. In the process of the invention a granulating liquid is used which is a suspension of 5-30% of microcrystalline cellulose-90% of which have a particle size that is lower than 50 Sg(m)m, and the amount of the microcrystalline cellulose refers to the final tablet mass in water and/or ethanol and/or isopropanol, and said suspension may contain also a part of the ingredients of the granules in dissolved form.
Bibliography:Application Number: EP20020727807