N-(MORPHOLIN-2YL) METHYL ACETAMIDE DERIVATIVES AS CCR-3 ANTAGONISTS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES

Compounds of formula (I); wherein: R represents substituted or unsubstituted heterocyclyl; Y represents -(CRnaRnb)n-; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 1 to 5; R represents unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R re...

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Main Authors HAYES, MARTIN ALISTAIR, HODGSON, SIMON TEANBY, LEWELL, XIAO QING, GORE, PAUL MARTIN, WILKINSON, MARK, KEELING, SUZANNE ELAINE, MILLS, GAIL, ELDRED, COLIN DAVID, HARRISON, LEE ANDREW, ANCLIFF, RACHAEL ANN, COOK, CAROLINE MARY, ROBERTSON, GRAEME MICHAEL, SWANSON, STEPHEN, WALKER, ANDREW JOHN, JUDD, DUNCAN BRUCE
Format Patent
LanguageEnglish
French
German
Published 12.01.2005
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of formula (I); wherein: R represents substituted or unsubstituted heterocyclyl; Y represents -(CRnaRnb)n-; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 1 to 5; R represents unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R represents hydrogen or C1-6alkyl; and salts and solvates thereof are CCR-3 antagonists and are thus indicated to be useful in therapy.
Bibliography:Application Number: EP20030745300