Modulation of the poliovirus receptor function

• Main Authors: EUSTACE, BRENDA K, ZEHETMEIER, CAROLIN, JAY, DANIEL G, UNGER, CHRISTINE MARGARETE, BESTE, GERALD, LAIN, BLANCA, TORELLA, CLAUDIA
• Format: Patent
• Language: English; French; German
• Published: 01.12.2004
• Edition: 7
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

A molecule specifically binding to at least one intra- or extracellular domain of the CD155 (cluster of differentiation 155), the poliovirus receptor (PVR), or any of their derivatives, where the molecule has the ability to modulate a receptor mediated adhesion, trafficking and/or invasion behavior of a cell expressing the CD155, the PVR, or any derivatives, is new. Independent claims are also included for the following: (1) a method of identifying and isolating the above molecule; (2) a nucleic acid molecule encoding the molecule cited above, or the ligand identified by the above method; (3) a vector comprising the above nucleic acid molecule; (4) a pharmaceutical composition comprising the above molecule, the molecules or ligands identified by the above method, the nucleic acid molecule or the vector, and/or a pharmaceutical carrier and/or diluent; (5) methods of modulating ex vivo the adhesion or invasion behavior of a cell expressing CD155, PVR or any of their derivatives; (6) a method of treating or preventing proliferative disorder or disease, cancer and/or metastasis; (7) a kit comprising the above molecule, molecules or ligands identified by the above method, the nucleic acid molecule or the vector, and suitable testing containers; and (8) a method of detecting and/or isolating cells expressing CD155, PVR or any derivatives. ACTIVITY : Cytostatic. No biological data given. MECHANISM OF ACTION : Gene therapy.