Method of screening compounds interacting with proteins of the p53 family

There is provided a method for screening an organic non-peptide compound for interaction with one or more domains of either a wild-type human protein of the p53 family or a mutant human protein of the p53 family, which interaction can stabilize a functional conformation thereof under physiological c...

Full description

Saved in:
Bibliographic Details
Main Authors CONNELL, RICHARD DAMIAN, RASTINEJAD, FARZAN, FOSTER, BARBARA ANN, COFFEY, HEATHER ANNE
Format Patent
LanguageEnglish
French
German
Published 21.06.2006
Subjects
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
Online AccessGet full text

Cover

More Information
Summary:There is provided a method for screening an organic non-peptide compound for interaction with one or more domains of either a wild-type human protein of the p53 family or a mutant human protein of the p53 family, which interaction can stabilize a functional conformation thereof under physiological conditions and promote wild-type activity of the protein of the p53 family, or restore wild-type activity to a mutant protein of the p53 family, which method comprises contacting said human protein of the p53 family, or one or more domains thereof, and said organic non-peptide compound, and monitoring the interaction thereof.
Bibliography:Application Number: EP20040020521