STEREOSELECTIVE TRANSACETALIZATION OF STEROIDAL C-22 ACETONIDE

The present invention is a process for the preparation of rofleponide of formula (II)where the 22R/22S ratio is 90/10 or greater which comprises contacting an acetonide of formula (I)with CH3-CH2-CH2-CHO (III) in the presence of perchloric acid where the concentration of the acetonide (I) is from ab...

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Bibliographic Details
Main Authors REEDER, LISA, M, STANCHINA, COREY, L
Format Patent
LanguageEnglish
French
German
Published 13.10.2004
Edition7
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Summary:The present invention is a process for the preparation of rofleponide of formula (II)where the 22R/22S ratio is 90/10 or greater which comprises contacting an acetonide of formula (I)with CH3-CH2-CH2-CHO (III) in the presence of perchloric acid where the concentration of the acetonide (I) is from about 1 g/20 ml to about 1 g/50 ml in the absence of an inert material.
Bibliography:Application Number: EP20020773277