CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY

The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings....

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Bibliographic Details
Main Authors ATSMA, Bem, MCEACHERN, Ernest, J, DI FLURI, Rosaria, Maria, BOGUCKI, David, NAN, Siquiao, WILSON, Trevor, HARWIG, Curtis, CRAWFORD, Jason, BRIDGER, Gary, J, SMITH, Christopher, Dennis, KALLER, Al, SKERLJ, Renato, T, SCHOLS, Dominique, ZHOU, Yuanxi
Format Patent
LanguageEnglish
French
German
Published 22.03.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
Bibliography:Application Number: EP20020805977