METHOD FOR MAKING A SELF-ASSEMBLING MONOLAYER ON A SUBSTRATE AND COATED SURFACE

• Main Authors: TATON, KRISTIN, S, GUIRE, PATRICK, E
• Format: Patent
• Language: English; French; German
• Published: 19.05.2010
• Subjects: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL; BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PERFORMING OPERATIONS; PHYSICS; PROCESSES FOR APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TOSURFACES, IN GENERAL; SPIRITS; SPRAYING OR ATOMISING IN GENERAL; TESTING; TRANSPORTING; VINEGAR; WINE

A surface coating composition for providing a self-assembling monolayer, in stable form, on a material surface or at a suitable interface, as well as a method of preparing such a composition and a method of using such a composition to coat a surface, such as the surface of an implantable medical device, in order to provide the surface with desirable properties. The method provides the covalent attachment of a SAM to a surface in a manner that substantially retains or improves the characteristics and/or performance of both the SAM and the surface itself. Covalent attachment is accomplished by the use of one or more latent reactive groups, e.g., provided by either the surface and/or by the SAM-forming molecules themselves.