OXALIPLATIN ACTIVE SUBSTANCE WITH A VERY LOW CONTENT OF OXALIC ACID

Oxaliplatin active substance comprises oxalic acid (wt.%) (=0.8, preferably = 0.05, especially less than 0.02). An independent claim is included for the preparation of oxaliplatin active substance involving (a) Reacting potassium tetrachloroplatinate (K2PtCl4) with trans-l-1,2-cyclohexanediamine in...

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Bibliographic Details
Main Author IBRAHIM, HOUSSAM
Format Patent
LanguageEnglish
French
German
Published 07.04.2004
Edition7
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Oxaliplatin active substance comprises oxalic acid (wt.%) (=0.8, preferably = 0.05, especially less than 0.02). An independent claim is included for the preparation of oxaliplatin active substance involving (a) Reacting potassium tetrachloroplatinate (K2PtCl4) with trans-l-1,2-cyclohexanediamine in an aqueous solution to obtain dichloro(trans-l-1,2-cyclohexanediamine)-platinum (II); (b) Adding silver nitrate (2 eq) to the product of step (A) to obtain diaquo(trans-l-1,2-cyclohexanediamine)-platinum (II); (c) Optionally adding potassium iodide or sodium iodide to the resulting solution, and adding active carbon under stirring; (d) Filtering and adding to the filtrate, alkali metal salt of oxalic acid, separating the oxaliplatin crystals formed by filtration and washing the crystals 2 - 5 times with water (pH 4.5 - 7); (e) Purifying oxaliplatin by recrystallisation to obtain crystals in a filter, where the crystals are washed 2 - 5 times with water (pH 4.5 - 7) to obtain the desired weight content of oxalic acid. - ACTIVITY : Cytostatic. - MECHANISM OF ACTION : None given.
Bibliography:Application Number: EP20020734974