ANTIGENS FOR IMMUNISATION

• Main Authors: DEMIN, ALEXANDR VIKTOROVICH, PONOMARENKO, NATALYA ALEXANDROVNA, KOLESNIKOV, ALEXANDR, VLADIMIROVICH, ALEXANDROVA, ELENA SERGEEVNA, VOROBIEV, IVAN IVANOVICH, GABIBOV, ALEXANDR GABIBOVICH
• Format: Patent
• Language: English; French; German
• Published: 03.03.2004
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The invention relates to biotechnology, immunology, gene engineering, and the microbiological and medical industries. The aim of the invention is to develop a method for producing catalytic antibodies to proteins and pcptidcs, in particular to gp120, using animals having spontaneous and induced autoimmune pathologies. Various methods for producing catalytic antibodies are also disclosed. The inventive methods make it possible to create a catalytic vaccine which can when injected to a patient to exhibits adhesive properties in relation to antigen simultaneously with a destructive function, there by suspending the progression of disease. Said invention discloses the inventive method for the autoimmunisation of animal lines SJL by fused proteins containing classical peptide epitope which develops pathology of an animal by protein fragments gp120 accompanied with an interest target catalytic antibody. The invention also comprises the method for immunising autoimmune animals by highly reactive chemical compositions which can perform a covalent selection of catalytic clones containing peptide fragments of potential resected portions gp120.