CYCLIC AMIDINE DERIVATIVE

• Main Authors: SATO, NOBUAKI, CLARK, RICHARD, NAOE, YOSHIMITSU, TSUKADA, ITARU, OKANO, KAZUO, HISHINUMA, IEHARU, KAJIWARA, AKIHARU, KOTAKE, MAKOTO, MIYAZAWA, SYUHEI, MATSUURA, FUMIYOSHI, TERAUCHI, TARO, OOHASHI, YOSHIAKI, KAWAHARA, TETSUYA, ITO, OSAMU, TANAKA, HIROSHI, SUZUKI, SHUICHI, KAMADA, ATSUSHI, OZAKI, FUMIHIRO, MIYAMOTO, MITSUAKI, SHINODA, MASANOBU
• Format: Patent
• Language: English; French; German
• Published: 18.03.2009
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a 2-iminopyrrolidine derivative selected from the group consisting of 1-(3-tert-butyl-4-methoxy-5-morpholino-phenyl)-2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydro-isoindol-2-yl)-ethanone; 1-{3-tert-butyl-5-[4-(2-hydroxy-acetyl)piperazin-1-yl]-4-methoxyphenyl}-2-(5,6-diethoxy-7-fluoro-1-imino-1,3-diyhdro-isoindol-2-yl)-ethanone; ethyl (4-{3-tert-butyl-5-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydro-isoindol-2-yl)-acetyl]-2-methoxy-phenyl}piperazin-1-yl)-acetate; 1-(3-tert-butyl-4-methoxy-5-piperazin-1-yl-phenyl)-2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydro-isoindol-2-yl)-ethanone, and (4-{3-tert-butyl-5-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydro-isoindol-2-yl)-acetyl]-2-methoxy-phenyl}-piperazin-1-yl)-acetic acid; and salts thereof.