Apparatus for displaying an image of all the chromosomes of a human cell

• Main Authors: CABIB, DARIO, GARINI, YUVAL, KATZIR, NIR, LAVI, MOSHE, WINE, DAVID, BUCKWALD, ROBERT A, SOENKSEN, DIRK G
• Format: Patent
• Language: English; French; German
• Published: 03.12.2003
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CALCULATING; CHEMISTRY; COLORIMETRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPUTING; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; COUNTING; DIAGNOSIS; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT,POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED,VISIBLE OR ULTRA-VIOLET LIGHT; MEASURING; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS; MEASURING LENGTH, THICKNESS OR SIMILAR LINEARDIMENSIONS; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; RADIATION PYROMETRY; SPIRITS; SURGERY; TESTING; VINEGAR; WINE

An apparatus for use in a method of detecting and analysing fluorescent in-situ hybridisations (fig. 5) employing numerous chromosome paints (fig. 9) each labelled with a different fluorophore or combination of fluorophores, the apparatus being highly sensitive both in spatial and spectral resolutions (fig. 6) such that it is capable of simultaneous detection of dozens of fluorophores or combinations of fluorophores (fig. 7) so as to enable the detection of a complete set of fluorescently painted human chromosomes (fig. 10).