Systems for the intrapulmonary delivery of aerosolized aqueous formulations

• Main Authors: SCHUSTER, JEFFREY ARTHUR, LLOYD, PETER M, RUBSAMEN, REID M, LLOYD, LESTER JOHN
• Format: Patent
• Language: English; French; German
• Published: 15.10.2008
• Subjects: ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; BABY COMFORTERS; CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS,e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES,DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES; CONVEYING; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR RECEIVING SPITTLE; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS; HANDLING THIN OR FILAMENTARY MATERIAL; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PACKAGES; PACKAGING ELEMENTS; PACKING; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; STORING; TRANSPORTING

A disposable package, comprising a container comprising at least one collapsible wall and configured for containing from about 10 mu L to about 300 mu L of a formulation comprising a pharmaceutically active drug and having a viscosity of less than or equal to about 50 centipoises; and a porous membrane comprising pores having a diameter in the range from about 0.25 microns to about 6 microns, wherein collapsing of the wall forces the formulation through the pores whereby the formulation is aerosolized.