ANTAGONISTS OF MCP-1 FUNCTION AND METHODS OF USE THEREOF

Compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inf...

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Main Authors INAGAKI, HIDEAKI, ROBINSON, LOUISE, KAKIGAMI, TAKUJI, MATSUMOTO, YUKIHARU, LABORDE, EDGARDO, VILLAR, HUGO, O, PETERSON, BRIAN, T, YOKOCHI, SHOJI, MATSUSHIMA, KOUJI, MENG, FANYING, ISHIWATA, YOSHIRO, ANUSKIEWICZ, STEVEN, E, JOMORI, TAKAHITO
Format Patent
LanguageEnglish
French
German
Published 21.12.2005
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephrtitis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection; pharmaceutical compositions comprising these compounds; and the use of these compounds and compositions in the prevention or treatment of such diseases.
Bibliography:Application Number: EP20020709746