NOVEL PLEUROMUTILIN DERIVATIVES

Pleuromutilin compounds of the formula (A) & (B) are of use in anti-bacterial therapy. in which: R 1 is optionally substituted C (1-6) alkyl or C (3-6) cycloalkyl or optionally substituted heterocyclyl; R 2 is vinyl or ethyl; R 3 is H, OH or F, and R 4 is H, or R 3 is H and R 4 is F, and R 5 and...

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Bibliographic Details
Main Authors FORREST, ANDREW, KEITH, JARVEST, RICHARD, LEWIS, SHEPPARD, ROBERT, JOHN, ELDER, JOHN, STEPHEN
Format Patent
LanguageEnglish
French
German
Published 15.10.2003
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Pleuromutilin compounds of the formula (A) & (B) are of use in anti-bacterial therapy. in which: R 1 is optionally substituted C (1-6) alkyl or C (3-6) cycloalkyl or optionally substituted heterocyclyl; R 2 is vinyl or ethyl; R 3 is H, OH or F, and R 4 is H, or R 3 is H and R 4 is F, and R 5 and R 6 together form an oxo group; or R 3 and R 4 is each H, R 5 is OH or H and R 6 is H, or R 5 is H and R 6 is OH or H.
Bibliography:Application Number: EP20010986687