METHOD FOR PREPARING SUBMICRON PARTICLE SUSPENSIONS OF PHARMACEUTICAL AGENTS

The present invention provides a method a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous, the process comprising the steps of (i) dissolving a first quanti...

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Bibliographic Details
Main Authors REBBECK, CHRISTINE, L, BRYNJELSEN, SEAN, WONG, JOSEPH, CHUNG, TAK, KIPP, JAMES, E, WERLING, JANE, SRIRAM, RAJARAM, DOTY, MARK, J
Format Patent
LanguageEnglish
French
German
Published 08.03.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a method a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous, the process comprising the steps of (i) dissolving a first quantity of the pharmaceutically-active compound in the water-miscible first organic solvent to form a first solution; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically-active compound to create a presuspension; and (iii) seeding the first solution or the second solvent prior to the mixing step or seeding the pre-suspension after the mixing step.
Bibliography:Application Number: EP20010998077