(E)-N-HYDROXY-3-(3-SULFAMOYL-PHENYL)-ACRYLAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention relates to compounds of the following formula, and pharmaceutically acceptable salts and solvates thereof, wherein: A is C 5-20 heteroaryl or C 5-20 carboaryl, and is optionally substituted; Q 1 is: a covalent bond, a saturated aliphatic C 1-7 alkylene group and is optionally s...

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Main Authors LOZA, EINARS, WATKINS, CLARE J, GAILITE, VIJA, HARRIS, C. JOHN, KALVINSH, IVARS, MOORE, KATHRYN G, FINN, PAUL W, RITCHIE, JAMES, ANDRIANOV, VICTOR, DUFFY, JAMES E. S, VORONA, MAXIM, ROMERO-MARTIN MARIA-ROSARIO, PISKUNOVA, IRINA, DIKOVSKA, KLARA, STARCHENKOV, IGOR
Format Patent
LanguageEnglish
French
German
Published 20.11.2013
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to compounds of the following formula, and pharmaceutically acceptable salts and solvates thereof, wherein: A is C 5-20 heteroaryl or C 5-20 carboaryl, and is optionally substituted; Q 1 is: a covalent bond, a saturated aliphatic C 1-7 alkylene group and is optionally substituted, or a partially unsaturated aliphatic C 2-7 alkylene group and is optionally substituted; R 1 is hydrogen, C 1-7 alkyl, or C 5-20 aryl; and, Q 2 is -(CH 2 ) n - where n is 4, 5, 6, or 7. The present invention also relates to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis.
Bibliography:Application Number: EP20010970011