"PSEUDO"-NATIVE CHEMICAL LIGATION

The present invention concerns methods and compositions for extending the technique of native chemical ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an amide bond (see FIG. 1 ). The invention further provides methods and uses for such proteins and deriva...

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Main Authors BOTTI, PAOLO, BRADBURNE, JAMES, A, KOCHENDOERFER, GERD, CHEN, SHIAH-YUN, HUNTER, CHRISTIE, L, LOW, DONALD, W, CRESSMAN, SONYA, KENT, STEPHEN, B. H
Format Patent
LanguageEnglish
French
German
Published 09.03.2011
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention concerns methods and compositions for extending the technique of native chemical ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an amide bond (see FIG. 1 ). The invention further provides methods and uses for such proteins and derivatized proteins. The invention is particularly suitable for use in the synthesis of optionally polymer-modified, synthetic bioactive proteins, and of pharmaceutical compositions that contain such proteins.
Bibliography:Application Number: EP20010952657