SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE

The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions includ...

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Main Authors FENTON, RICK, WOOD, RHONDA, LONG, SCOTT, A, LINDMARK, RICHARD, HAYES, MICHAEL, J, TRUJILLO, JOHN, I, DICE, TOM, MAHONEY, MATTHEW, W, CASE, BRENDA, PARLOW, JOHN, J, WANG, CHINGNG, SOUTH, MICHAEL, S, HUANG, WEI, HUANG, HORNGIH, NEUMANN, WILLIAM, L, JONES, DARIN, E, FRANKLIN, GARY, W, RUEPPEL, MELVIN, L, KUSTURIN, CARRIE, REITZ, DAVID
Format Patent
LanguageEnglish
French
German
Published 19.03.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
Bibliography:Application Number: EP20000980582