Antibodies against the IL-8 receptor, and their therapeutic uses

• Main Authors: TEKAMP-OLSON, PATRICIA A, MULLENBACH, GUY, WERNETTE-HAMMOND, MARY ELLEN
• Format: Patent
• Language: English; French; German
• Published: 12.02.2003
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

An inhibitor to IL8 receptor-binding comprising an antibody or fragment thereof that is capable of interacting with the amino-terminal extracellular domain of an IL8 receptor and that is capable of competing with IL8 for binding to the receptor, wherein the antibody is obtainable by immunising a mammal with an immunogen that consists essentially of a polypeptide selected from F-E-D-F-W-K-G-E-D-L-S-N-Y-S-Y, S-S-T-L-P-P-F-L-L-D-A-A-P-C and F-L-L-D-A-A-P-C-E-P-E-S-L-E-I. The antibodies are useful modulators of IL8 receptor-mediated biological activity.