2'-O-ACETAMIDO MODIFIED MONOMERS AND OLIGOMERS

Nucleosidic monomers and oligomeric compounds prepared therefrom are provided. Also provided is a novel method of deprotection of oligomeric compounds. Oligomeric compounds having at least one 2'-O-acetamido modified nucleosidic monomer are expected to have increased nuclease resistance and bin...

Full description

Saved in:
Bibliographic Details
Main Authors KAWASAKI, ANDREW, M, FRASER, ALLISTER, S, PRAKASH, THAZHA P, MANOHARAN, MUTHIAH, COOK, PHILLIP, DAN
Format Patent
LanguageEnglish
French
German
Published 31.12.2008
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:Nucleosidic monomers and oligomeric compounds prepared therefrom are provided. Also provided is a novel method of deprotection of oligomeric compounds. Oligomeric compounds having at least one 2'-O-acetamido modified nucleosidic monomer are expected to have increased nuclease resistance and binding affinity to a complementary strand of nucleic acid. Such oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions responsive to oligonucleotide therapeutics.
Bibliography:Application Number: EP20000955583