PARENTERAL CISPLATIN EMULSION

A sterile pharmaceutical cisplatin composition as an oil-in-water emulsion having low toxicity for parenteral administration comprising:a) an oily phase selected from the group consisting of: vegetable oils, esters of medium or long chain fatty acids, and fractionated or modified oils;b) cisplatin i...

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Bibliographic Details
Main Authors RIVANKAR, SANGEETA HANURMESH, PAI, SRIKANTH ANNAPPA, KOCHAREKAR, SHILPA SUDHAKAR
Format Patent
LanguageEnglish
French
German
Published 15.05.2002
Edition7
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A sterile pharmaceutical cisplatin composition as an oil-in-water emulsion having low toxicity for parenteral administration comprising:a) an oily phase selected from the group consisting of: vegetable oils, esters of medium or long chain fatty acids, and fractionated or modified oils;b) cisplatin incorporated in the oily phase;c) an emulsifier selected from the group consisting of: natural phosphatides; modified phosphatides, and synthetic non-ionic surfactants;d) a tonicity modifying agent selected from the group of compounds consisting of: glycerin, mannitol, and dextrose;e) a chelating agent selected from the group of compounds consisting of: edetates, and desferrioxamine mesylate; andf) water.
Bibliography:Application Number: EP20000956778