Method for determination of chromatographic media parameters in packed beds of hydrophobic polymer particles

An improved method for measuring the chromatographic properties, such as excluded volume, of hydrophobic polymer substrates is disclosed. Use of 0.05-1 micron sized crosslinked ionically-charged polymer particles, especially emulsion-form or ground polymer particles, as a large-molecule probe, allow...

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Bibliographic Details
Main Author MAIKNER, JOHN JOSEPH
Format Patent
LanguageEnglish
French
German
Published 15.04.2009
Subjects
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PHYSICS
SEPARATION
TESTING
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:An improved method for measuring the chromatographic properties, such as excluded volume, of hydrophobic polymer substrates is disclosed. Use of 0.05-1 micron sized crosslinked ionically-charged polymer particles, especially emulsion-form or ground polymer particles, as a large-molecule probe, allows environmentally friendly aqueous-based solvent systems to be used as mobile phases to characterize hydrophobic polymer supports for use in analytical or preparative scale chromatographic applications. This method eliminates the use of non-polar organic solvents that is required when conventional non-polar large-molecule probes (such as polystyrene) are used to characterize chromatographic media.
Bibliography:Application Number: EP20010306560