COMPOSITIONS OF SOLVENTS AND HIGH CONCENTRATIONS OF NUCLEIC ACID ANALOGS
The invention provides compositions and methods suitable for dissolving nucleic acid analogs with uncharged, neutral backbones at high concentrations at approximately neutral pH. By using the compositions of the invention, which include a polar, aprotic solvent, concentrations of nucleic acid analog...
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Main Authors | , , , |
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Format | Patent |
Language | English French German |
Published |
06.02.2002
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | The invention provides compositions and methods suitable for dissolving nucleic acid analogs with uncharged, neutral backbones at high concentrations at approximately neutral pH. By using the compositions of the invention, which include a polar, aprotic solvent, concentrations of nucleic acid analogs such as PNA can be achieved in the range of approximately 1 muM to 10 mM. |
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Bibliography: | Application Number: EP20000928984 |