PROCESS FOR THE PRODUCTION OF TERT-BUTYL (E)-(6-¬2-¬4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-¬METHYL(METHYLSULFONYL)AMINO PYRIMIDIN-5-YL VINYL (4R,6S)-2,2-DIMETHYL¬1,3 DIOXAN-4-YL)ACETATE

The invention concerns a process for the manufacture of tert-butyl (E)-(6-[2-4-(4-flourophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]vinyl)-(4R,6S)-2,2-dimethyl[1,3]-dioxan-4-yl)acetate, the novel starting material used in said process and the use of the process in the manufactu...

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Bibliographic Details
Main Authors DIORAZIO, LOUIS, JOSEPH, TAYLOR, NIGEL, PHILIP, KABAKI, MIKIO, KOIKE, HARUO
Format Patent
LanguageEnglish
French
German
Published 26.11.2008
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention concerns a process for the manufacture of tert-butyl (E)-(6-[2-4-(4-flourophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]vinyl)-(4R,6S)-2,2-dimethyl[1,3]-dioxan-4-yl)acetate, the novel starting material used in said process and the use of the process in the manufacture of a pharmaceutical.
Bibliography:Application Number: EP20000903810