PHOSPHONIC ACID DERIVATIVES HAVING CARBOXYPEPTIDASE B INHIBITORY ACTIVITY

• Main Authors: KANEMOTO, KENICHI, SATOH, ERIKO, FUSHIHARA, KENICHI, KIKUCHI, CHIKA, MATSUSHIMA, TETSUYA, SUZUKI, KOKICHI, YAMAMOTO, TAKEHIRO
• Format: Patent
• Language: English; French; German
• Published: 23.01.2002
• Edition: 7
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R represents hydrogen atom, an alkyl group, a substituted alkyl group and the like; R and R represent hydrogen atom, an alkyl group, a substituted alkyl group, an alkoxyl group and the like; X represents -CH2-, -O-, or -NH-; A represents the following group (II): Äin which R and R represent hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group and the like; R and R represents hydrogen atom, a halogen atom, hydroxyl group, phenyl group, an alkyl group and the likeÜ and the like; and E represents hydrogen atom and the like, which has inhibitory activity against carboxypeptidase B and is useful for therapeutic and/or preventive treatment of a thrombotic disease.