PHOSPHONIC ACID DERIVATIVES HAVING CARBOXYPEPTIDASE B INHIBITORY ACTIVITY

A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R represents hydrogen atom, an alkyl group, a substituted alkyl group and the like; R and R represent hydrogen atom, an alkyl group, a substituted alkyl group, an alkoxyl group and th...

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Main Authors KANEMOTO, KENICHI, SATOH, ERIKO, FUSHIHARA, KENICHI, KIKUCHI, CHIKA, MATSUSHIMA, TETSUYA, SUZUKI, KOKICHI, YAMAMOTO, TAKEHIRO
Format Patent
LanguageEnglish
French
German
Published 23.01.2002
Edition7
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R represents hydrogen atom, an alkyl group, a substituted alkyl group and the like; R and R represent hydrogen atom, an alkyl group, a substituted alkyl group, an alkoxyl group and the like; X represents -CH2-, -O-, or -NH-; A represents the following group (II): Äin which R and R represent hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group and the like; R and R represents hydrogen atom, a halogen atom, hydroxyl group, phenyl group, an alkyl group and the likeÜ and the like; and E represents hydrogen atom and the like, which has inhibitory activity against carboxypeptidase B and is useful for therapeutic and/or preventive treatment of a thrombotic disease.
Bibliography:Application Number: EP20000960970