IL-5 INHIBITING 6-AZAURACIL DERIVATIVES

• Main Authors: FREYNE, EDDY J. E, LACRAMPE, JEAN FERNAND ARMAND, DEROOSE, FREDERIK DIRK, PETIT, DAVY P. F. M
• Format: Patent
• Language: English; French; German
• Published: 19.09.2001
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention is concerned with the compounds of formulathe N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to 3; q is 0 to 5; -A-B- is -(CH2)r-, -(CH2)t-O-, -(CH2)t-S(=O)u- or -(CH2)t-NR3-; r is 2 to 4; t is 1 to 3; u is 0 to 2; X1 is O, S, NR3 or a direct bond; R1 and R4 are C1-6alkyl, halo, polyhaloC1-6alkyl, hydroxy, mercapto, C1-6alkyloxy, C1-6alkylthio, C1-6alkylcarbonyloxy, aryl, cyano, nitro, Het3, R6, NR7R8 or C1-4alkyl substituted with Het3, R6 or NR7R8; R2 represents aryl, Het1, C3-7cycloalkyl, cyano, C1-6alkyl, -C(=Q)-X2-R15 or C1-6alkyl substituted with one or two substituents selected from hydroxy, cyano, amino, mono- or di(C1-4alkyl)amino, C1-6alkyloxy, C1-6alkylsulfonyloxy, C1-6alkyloxycarbonyl, C3-7cycloalkyl, aryl, aryloxy, arylthio, Het1, Het1 oxy, Het1 thio and -C(=Q)-X2-R15; R3 is hydrogen or C1-4alkyl; R15 is hydrogen, optionally substituted C1-6alkyl, C3-7cycloallcyl, aryl; where X2 is a direct bond, R15 is also halo or Het1; where X2 is NR5, R15 is also hydroxy; where X2 is C(=O)-NH-NH or NH-NH-C(=O), R15 is replaced by R11; R5 is hydrogen, C1-6alkyl,