Piperidine and piperazine compounds for use in the treatment of Alzheimer

• Main Authors: KARIBE, NORIO, OGURA, HIROO, KOSASA, MICHIKO, HIGURASHI, KUNIZOU, ARAKI, SHIN, TSUCHIYA, YUTAKA, KOSASA, TAKASHI, SASAKI, ATSUSHI, IIMURA, YOUICHI, YAMATSU, KIYOMI, KUSOTA, ATSUHIKO, YAMANISHI, YOSHIHARU, SUGITOMO, HACHIRO
• Format: Patent
• Language: English; French; German
• Published: 18.07.2001
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A cyclic amine compound or a salt thereof is defined by the formula: in which J is (a) an optionally substituted group selected from (1) phenyl, (2) pyridyl, (3) pyrazyl, (4) quinolyl, (5) cyclohexyl, (6) quinoxalyl and (7) furyl; (b) a monovalent or divalent group, in which the phenyl may have a substituent(s) selected from the group consisting of (1) indanyl, (2) indanonyl, (3) indenyl, (4) indenonyl, (5) indanedionyl, (6) tetralonyl, (7) benzosuberonyl, (8) indanolyl and (9) C6H5-CO-CH(CH3)-; (c) a monovalent group derived from a cyclic amide compound; (d) a lower alkyl; or (e) a group of R -CH=CH- in which R is hydrogen or a lower alkoxycarbonyl; B is a bridging group; T is a nitrogen; Q is nitrogen, carbon or >N->0; q is an integer of 1 to 3; K is hydrogen, an optionally substituted phenyl group, an arylalkyl in which the phenyl may have a substituent, cynnamyl, a lower alkyl, pyridylmethyl, a cycloalkylalkyl, adamantanemethyl, furylmethyl, a cycloalkyl, a lower alkoxycarbonyl or an acyl; and --- shows a single bond or a double bond. The compound is useful for the preparation of pharmaceutical compositions and for medicaments effective against senile dementia.