Shaped body for the retention of pyrogenes, process for its manufacture and use thereof

• Main Authors: NOTHDURFT, ANNEKATRIN, NIKLAS, THORSTEN, WECHS, FRIEDBERT
• Format: Patent
• Language: English; French; German
• Published: 27.06.2001
• Edition: 7
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; SEPARATION; THEIR PREPARATION OR CHEMICAL WORKING-UP; TRANSPORTING; TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE; WORKING-UP

Die Erfindung beschreibt hydrophil wirkende Formkörper, insbesondere semipermeable Membranen zur Pyrogenrückhaltung umfassend eine synthetische Polymerkomponente und ein Additiv aus einem Copolymer aus Vinylpyrrolidon und einer Vinylimidazol-Verbindung und ferner Verfahren zu Herstellung der Formkörper. Die erfindungsgemäßen Formkörper weisen ein derart hohes Pyrogenrückhaltevermögen auf, dass die in den Filtraten vorhandenen Pyrogenkonzentrationen teilweise unterhalb der Erfassungsgrenze des Gel-clot-LAL-Tests liegen. Hydrophilic membrane comprises a synthetic polymer and an additive which is a copolymer of vinylpyrrolidone (I) and a vinylimidazole compound (II). An Independent claim is also included for production of the membrane which comprises preparing a solution containing the synthetic polymer, forming the solution into a membrane, precipitating the polymer by heat or with a non-solvent, and washing and drying the membrane and optionally treating it with a wetting agent. The additive is added to the polymer solution before or after forming the membrane.