USE OF PIPERIDINES AND/OR PIPERAZINES AS INHIBITORS OF P38-ALPHA KINASE

The invention is directed to methods to treat conditions mediated by p38-alphakinase using compounds of the formulaand the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof,whereinZ is N or CR1, R1 is a noninterfering substituent,each of X1 and X2 is a linker,Ar1 and...

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Main Authors LIU, DAVID, Y, CHAKRAVARTY, SARVAJIT, LEWICKI, JOHN, A, LUEDTKE, GREGORY, R, MAVUNKEL, BABU, J, DUGAR, SUNDEEP, GOEHRING, R., RICHARD, SCHREINER, GEORGE, F
Format Patent
LanguageEnglish
French
German
Published 20.06.2001
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention is directed to methods to treat conditions mediated by p38-alphakinase using compounds of the formulaand the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof,whereinZ is N or CR1, R1 is a noninterfering substituent,each of X1 and X2 is a linker,Ar1 and Ar2 are identical or different, and represent optionally substituted C1-C20 hydrocarbyl residues wherein at least one of Ar1 and Ar2 is an optionally substituted aryl group, with the proviso that when X2 is CH2 or an isostere thereof, X1 is CO or an isostere thereof, and Ar2 is optionally substituted phenyl, Ar1 is other than an optionally substituted indolyl, benzimidazolyl or benzotriazolyl substituent, and wherein said optionally substituted phenyl is not an optionally substituted indolyl, benzimidazolyl, or benzotriazolyl,Y is a noninterfering substituent, wherein n is an integer from 0-4, andwherein m is an integer from 0-4 and 1 is an integer from 0-3.
Bibliography:Application Number: EP19990945316