4-hydroxy-4-phenylpiperidine derivatives having opioid agonist activity and pharmaceuticals containing the same

Described is a 4-hydroxy-4-phenylpiperidine derivative represented by the following formula (1): Äwherein, R and R are the same or different and each independently represents a hydrogen atom, a lower alkyl, or the like, R represents a hydrogen atom or a group -(CR R )n-Y (in which, R and R each repr...

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Main Authors KANAMARU, YOSHIHIKO, KOMOTO, TERUO, OKA, TETSUO, UMEHARA, NORIMITSU, KAWAMOTO, NORIYUKI, MOGI, KINICHI, SATO, SUSUMU
Format Patent
LanguageEnglish
French
German
Published 25.08.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Described is a 4-hydroxy-4-phenylpiperidine derivative represented by the following formula (1): Äwherein, R and R are the same or different and each independently represents a hydrogen atom, a lower alkyl, or the like, R represents a hydrogen atom or a group -(CR R )n-Y (in which, R and R each represents a hydrogen atom or a lower alkyl group, Y represents a group -COOR , -CONR R , -OR or -OCOR (in which R , R and R each independently represents a hydrogen atom, a lower alkyl group, or the like, R and R are the same or different and each independently represents a hydrogen atom, a lower alkyl group, or the like), and n stands for 1 to 6)Ü, or salt thereof. The compound exhibits excellent peripheral analgesic action.
Bibliography:Application Number: EP20000123487