SOLID SUPPORTED SYNTHESIS OF SULFONATED 2-OXOPIPERAZINES

The subject invention involves processes for making 2-oxopiperazine and homologous compounds using a solid support resin by (a) removing the protecting group from a N-protected amino acid ester of the resin (if present), (b) reacting the resulting unprotected resin ester with a sulfonyl chloride, (c...

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Bibliographic Details
Main Authors GOLEBIOWSKI, ADAM, KLOPFENSTEIN, SEAN, REES
Format Patent
LanguageEnglish
French
German
Published 07.02.2001
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The subject invention involves processes for making 2-oxopiperazine and homologous compounds using a solid support resin by (a) removing the protecting group from a N-protected amino acid ester of the resin (if present), (b) reacting the resulting unprotected resin ester with a sulfonyl chloride, (c) reacting the resulting intermediate with a N-protected amino alcohol, (d) removing the N-protecting group from the N from the amino alcohol, and (e) cleaving/cyclizing the product from the resin.
Bibliography:Application Number: EP19990920061