PIPERAZINES AS INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHATASE (FBPase)

Compounds of formula A are disclosed: wherein R1 is aralkyl or cycloalkyl; R2 is cycloalkylmethyl, alkyl, or aralkyl; R3 is hydrogen, alkyl, substituted phenyl (including p-phenoxy-phenyl), or fluorene; R4 is hydrogen, alkyl, substituted phenyls (including 1-alkyl-4-carboxy-substituted phenyls), alk...

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Main Authors SHORT, KEVIN, MICHAEL, KIMMICH, RACHEL, DENISE, ANNE, MASON, JAMES, CHRISTOPHER, JONES, TODD, KEVIN, ARIENTI, KRISTEN, LEE, MJALLI, ADNAN, M., M
Format Patent
LanguageEnglish
French
German
Published 12.09.2001
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of formula A are disclosed: wherein R1 is aralkyl or cycloalkyl; R2 is cycloalkylmethyl, alkyl, or aralkyl; R3 is hydrogen, alkyl, substituted phenyl (including p-phenoxy-phenyl), or fluorene; R4 is hydrogen, alkyl, substituted phenyls (including 1-alkyl-4-carboxy-substituted phenyls), alkyl carboxylic acids; R5 is hydrogen or R1 and R5 taken together forming a tetrahydroisoquinoline ring or a piperidine ring. These compounds exhibit inhibitory action against fructose-1,6-bisphosphatase (FBPase) and are indicated in the treatment or management of Type II diabetes.
Bibliography:Application Number: EP19990912505