15-MEMBERED LACTAMS KETOLIDES WITH ANTIBACTERIAL ACTIVITY

The present invention relates to the new 15-membered ketoazalides from the class of 6-O-methyl-8a-aza-8a-homo-and 6-O-methyl-9a-aza-9a-homoerythromycin A with the general formula (I) wherein A represents NH group and B at the same time represents C=O group, or A represents C=O group and B at the sam...

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Bibliographic Details
Main Authors KELNERIC,ZELJKO, KOBREHEL, GABRIJELA, LAZAREVSKI, GORJANA
Format Patent
LanguageEnglish
French
German
Published 24.01.2001
Edition7
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:The present invention relates to the new 15-membered ketoazalides from the class of 6-O-methyl-8a-aza-8a-homo-and 6-O-methyl-9a-aza-9a-homoerythromycin A with the general formula (I) wherein A represents NH group and B at the same time represents C=O group, or A represents C=O group and B at the same time represents NH group, R1 represents OH group, L-cladinosyl group of the formula (II) or together with R2 represents ketone, R2 represents hydrogen or together with R1 represents ketone, R3 represents hydrogen or C1-C4alkanoyl group, to intermediates and a process for their preparation, to their pharmaceutically acceptable addition salts with inorganic or organic acids, to the process for the preparation of pharmaceutical compositions, as well as to the use of pharmaceutical compositions for treating bacterial infections.
Bibliography:Application Number: EP19990911955